The FLEXcyte 96 brings in vitro contraction force measurements of cardiac cells to a new dimension. By using a well-defined, flexible substrate for cardiac cells, the system leverages maturity and mature responses of stem cell-derived cardiomyocytes to pharmacological compounds in a higher throughput format. In the 96-well plate, the cells adhere as monolayers on the flexible substrates and the contractility of the synchronized cell layers are recorded. This unique technology allows for recordings in a native-like environment close to mechanical conditions of the heart. The FLEXcyte 96 is a turn-key system for structural and functional contraction force recordings in cardiotoxicity, safety and efficacy screening and basic research.

The FLEXcyte 96 comes as an add-on for the CardioExcyte 96. With less than 10 μm in thickness and sophisticated surface modification, the polydimethylsiloxane (PDMS) membranes of the FLEXcyte 96 disposable plates offer physiological elasticity of native human heart tissue and strong mechanical support. While being deflected by the weight of the culture medium, rhythmic contraction of the cardiomyocytes lift the membranes in the 96-well upwards. By measuring the changes in deflection, the mechanical stress can be calculated.

The system has been validated with stem cell-derived cardiomyocytes from several providers (Ncardia, FUJIFILM Cellular Dynamics, Inc. (FCDI), Axol and NEXEL). Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC- CMs) display positive inotropic responses, no additional stimulation of “cell maturation” is necessary. Cardiac contraction force can also be measured on patient-derived cells.

 

 

  1. Special Requirements: Medical equipment often has specific needs, such as temperature control or shock absorption. For example, certain medications must remain at a specific temperature throughout the supply chain. This may require insulated containers, refrigerated vehicles, and specialized warehousing.

  2. Custom Packaging: Custom packaging solutions are essential for medical equipment. A professional crating company can provide protective packaging tailored to the unique requirements of each product. This can include foam packaging die-cut to the exact shape needed for the product.

  3. Reusable Packaging: For regular shipments, reusable packaging can be a cost-effective and environmentally friendly option. These crates can be assembled and disassembled without tools and can be fully customized.

  4. International Shipping: When shipping internationally, it's important to be aware of customs regulations. Failure to comply can result in delays, returns, or fines. Professional shipping companies can help obtain the necessary permits and documentation.

  5. Insurance and Tracking: Given the high cost and critical nature of medical equipment, insurance is essential. Tracking can also provide peace of mind and help prevent loss.

What type of medical equipment do you offer?

We offer a wide range of medical equipment from imaging devices to surgical instruments.

How do I know which equipment suits my needs?

Our product specialists can help you identify the most suitable equipment based on your specific requirements.

Is there a minimum order quantity?

This varies per product. Please consult the product details or speak with our sales team.

How can I get a quote?

You can request a quote online or speak directly with our sales representatives for more information.

Do you offer financing options?

Yes, we offer various financing options to qualified customers.

Is there a discount for bulk purchases?

Discounts may be available depending on the quantity and type of equipment.

What is the standard delivery time?

Standard delivery times vary depending on the product and location.

Do you offer international shipping?

Yes, we ship to various countries subject to local regulations.

How can I track my order?

You will receive a tracking number once your order has been dispatched.

What is the warranty period for your equipment?

Warranty periods differ by product and can range from 1 to 5 years.

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